Acousto-optic imaging (AOI) enables optical-contrast imaging deep inside scattering samples via localized ultrasound-modulation of scattered light. While AOI allows optical investigations at depths, its imaging resolution is inherently limited by the ultrasound wavelength, prohibiting microscopic investigations. Here, we propose a computational imaging approach that allows optical diffraction-limited imaging using a conventional AOI system. We achieve this by extracting diffraction-limited imaging information from speckle correlations in the conventionally detected ultrasound-modulated scattered-light fields. Specifically, we identify that since ``memory-effect'' speckle correlations allow estimation of the Fourier magnitude of the field inside the ultrasound focus, scanning the ultrasound focus enables robust diffraction-limited reconstruction of extended objects using ptychography (i.e., we exploit the ultrasound focus as the scanned spatial-gate probe required for ptychographic phase retrieval). Moreover, we exploit the short speckle decorrelation-time in dynamic media, which is usually considered a hurdle for wavefront-shaping- based approaches, for improved ptychographic reconstruction. We experimentally demonstrate noninvasive imaging of targets that extend well beyond the memory-effect range, with a 40-times resolution improvement over conventional AOI.
Lensless flexible fiber-bundle-based endoscopes allow imaging at depths beyond the reach of conventional microscopes with a minimal footprint. These multicore fibers provide a simple solution for wide-field fluorescent imaging when the target is adjacent to the fiber facet. However, they suffer from a very limited working distance and out-of-focus background. Here, we carefully study the dynamic speckle illumination patterns generated by bending a commercial fiber bundle and show that they can be exploited to allow extended working distance and background rejection, using a super-resolution fluctuations imaging analysis of multiple frames, without the addition of any optical elements.
We demonstrate an approach that allows taking videos at very high frame-rates of over 100,000 frames per second by exploiting the fast sampling rate of the standard rolling-shutter readout mechanism, common to most conventional sensors, and a compressive-sampling acquisition scheme. Our approach is directly applied to a conventional imaging system by the simple addition of a diffuser to the pupil plane that randomly encodes the entire field-of-view to each camera row, while maintaining diffraction-limited resolution. A short video is reconstructed from a single camera frame via a compressed-sensing reconstruction algorithm, exploiting the inherent sparsity of the imaged scene.