Research

What do we do?

At the Advanced Imaging Lab we are developing new optics-based techniques that can look deep into opaque samples and also around corners, by combining controlled lightsound and advanced computational approaches, going way beyond what conventional cameras can do.

The research at our group lies at the interface between physics and engineering, and focuses on developing novel computational-based optical imaging techniques to overcome the limitations of current approaches. One important challenge that we try to address is the limitations imposed by light scattering on optical microscopy. Our methods challenge some intuitive notions on randomly scattered light, such as the light reflected off walls, by showing that it is possible to use it or extract information from it for imaging.

Why do we do it?

First, because everyone wants to have superman vision (or at least a CSI 'enhance' capability to 'zoom in on that reflection'). More seriously, almost any object that we see around us in not transparent. And it is not transparent not because it absorbs light but because of light scattering, which happens at any interface between two media. That's the reason why we cannot see objects that are hidden in dense fog or below our skin, even though the scattered light seems to pass through the obstacle, a problem of great practical importance in many fields.

Why should we succeed?

Although random, light scattering is a deterministic process, and utilizing the latest digital light control devices and computational approaches, scattering can be measured, undone, and even exploited by carefully shaping the optical light-field. And that's exactly what we're doing!

Excellent recent reviews

[1] S. Yoon et al. “Deep optical imaging within complex scattering media”, Nature 2, 141 (2020).

[2] Z. Merali “Optics: Super vision”, Nature 518, 158 (2015).

[3] R. Horstmeyer et al. "Guidestar-assisted wavefront-shaping methods for focusing light into biological tissue", Nature Photonics 9, 563-571 (2015).

[4] A.P. Mosk et al. "Controlling waves in space and time for imaging and focusing in complex media", Nature Photonics 6, 283–292 (2012).

[5] D.S. Wiersma "Disordered Photonics", Nature Photonics 7, 188–196 (2013).

Resarch Topics

Optical imaging through scattering media

High-resolution imaging and light control through highly scattering media such as tissues and fog are fundamental problems that are important for a variety of applications, ranging from microscopy, through manipulation of cells and molecules, to astronomy. Read more!

Lensless Micro-endoscopy

Micro-endoscopes use optical fibers to obtain microscopic images deep inside the body while keeping the tissue damage as low as possible and requiring no electronics or cameras inside the body. We aim to improve a variety of methods for many applications: from clinical procedures, through biomedical investigations, all the way to in-vivo deep-tissue imaging. Read more!

Acousto-optic tomography

Acousto-optic imaging (AOI) enables optical-contrast imaging deep inside scattering samples via localized ultrasound-modulation of scattered light. We aim to surpass the acoustic diffraction limit and achieve high-resolution imaging at depths with standard AOT systems. Read more!

Photoacoustic/Optoacoustic imaging

Photoacoustic-tomography is a noninvasive imaging technique which combines light and sound, based on optical generation of ultrasound waves. We aim at developing approaches to overcome the two main limitations of photoacoustic imaging today: aberrations in complex samples and the limited spatial-resolution. Read more!

Resolution improvement in ultrasound imaging

We are trying to implement super-resolution methods, mostly from optical imaging, in ultrasound imaging modalities to overcome the system's acoustic diffraction limit. Read more!

Optical imaging through scattering media

 

endoscopy

ao_image

pa_img

us_img