Patents

Treatment of mood and stress-related disorder

Raz Yirmiya, Tirzah Kreisel         

Publication Number                Filing Date                  Publication Date

US 20160199448                    2014-08-20                  2016-07-14

A pharmaceutical composition and method for treating or attenuating a mood or stress-related disorder in a subject having normal or low inflammatory state is provided. In some embodiments, the pharmaceutical composition and method of the invention comprise activating or stimulating microglia for treatment of mood or stress-related disorder. 

Antisense oligonucleotides against AChE in the treatment of gastrointestinal inflammation disorders

Hermona Soreq, Raz Yirmiya         

Publication Number                Filing Date                  Publication Date

US 8722876                            2013-05-22                  2014-05-13 

AChE antisense oligonucleotides are used as antiinflammatory agents, such oligonucleotides preferably having the sequence of SEQ ID NO:1 and SEQ ID NO:7. Methods of treatment of inflammatory conditions, as well as fever, and particularly inflammation of the gastrointestinal tract, are described.

AChE antisense deoxyoligonucleotide as an anti-inflammatory agent    

Hermona Soreq, Raz Yirmiya, Amir Dori Itzhak Wirguin Gal Ifergane

Publication Number                Filing Date                  Publication Date

EP 2599489 A                                    2004-10-26                  2013-06-05

The present invention provides a novel use for AChE antisense oligonucleotides as anti-inflammatory agents, wherein said oligonucleotides are preferably as denoted by SEQ. ID. NO:1, SEQ. ID. NO:2 and SEQ. ID. NO:7. Described are pharmaceutical compositions for the treatment of inflammatory conditions comprising as active agent said AChE antisense oligonucleotides. 

AChE ANTISENSE OLIGONUCLEOTIDE AS AN ANTI-INFLAMMATORY AGENT

Hermona Soreq, Raz Yirmiya, Amir Dori Itzhak Wirguin Gal Ifergane          

Publication Number                Filing Date                  Publication Date

US 20130018081                    2012-01-16                  2013-01-17

Disclosed is a novel use for AChE antisense oligonucleotides as anti-inflammatory agents, wherein said oligonucleotides are preferably as denoted by SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:7. Methods of treatment of inflammatory conditions, as well as fever, and particularly inflammation-associated neuropathies such as Guillain-Barré Syndrome, are described.

Method for assessing trait anxiety by determining cholinergic status     

Hermona Soreq Ella Sklan Raz Yirmiya Keren Ailon Irit Shapira-Lichter

Publication Number                Filing Date                  Publication Date

US 7494783                            2006-04-10                  2009-02-24

The invention provides methods/kits for assessing levels of trait or state anxiety in a subject by comparing genotypes and/or expression patterns at the ACHE, PON1 and/or BChE genes to the genotype and/or expression pattern of the genes in a reference population whose genotype and/or expression pattern of the genes is known or by correlating AChE levels activity to those of PON.

AChE antisense oligonucleotide as an anti-inflammatory agent  

Hermona Soreq, Amir Dori Itzhak Wirguin Gal Ifergane, Raz Yirmiya

Publication Number                Filing Date                  Publication Date

US 20090005331                    2007-04-18                  2009-01-01

Disclosed is a novel use for AChE antisense oligonucleotides as anti-inflammatory agents, wherein said oligonucleotides are preferably as denoted by SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:7. Methods of treatment of inflammatory conditions, as well as fever, and particularly inflammation-associated neuropathies such as Guillain-Barré Syndrome, are described.

AChE antisense deoxyoligonucleotide as an anti-inflammatory agent    

Hermona Soreq, Raz Yirmiya

Publication Number                Filing Date                  Publication Date

EP 2599489 A1                      2004-10-26                  2013-06-05 

The present invention provides a novel use for AChE antisense oligonucleotides as anti-inflammatory agents, wherein said oligonucleotides are preferably as denoted by SEQ. ID. NO:1, SEQ. ID. NO:2 and SEQ. ID. NO:7. Described are pharmaceutical compositions for the treatment of inflammatory conditions comprising as active agent said AChE antisense oligonucleotides.

See also Raz Yirmiya's site at Yissum (Research Development Company of the Hebrew University of Jerusalem Ltd.): https://covalentdata.com/institution/hebrew-university-of-jerusalem/port...